How maternal B cells help the fetus avoid immune rejection
Official title: Maternal B cells enforce fetal tolerance
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10992108 · Data updated 2026-11-12
This study is looking at how a mother's immune cells help her body accept her baby during pregnancy, with the hope of finding ways to make pregnancies healthier and improve the well-being of newborns.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $193,212 |
| NIH project number | 5K08AI180350-02 |
| Project ID | NIH-10992108 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women, particularly those at risk for complications related to immune tolerance during pregnancy.
✕Less likely to help
Patients who are not pregnant or those with conditions unrelated to pregnancy or fetal development may not benefit from this research.
What this research studies
This research investigates the role of maternal B cells in promoting fetal tolerance, which is crucial for healthy pregnancies. By understanding how these immune cells function, the study aims to develop strategies that could improve pregnancy outcomes and the health of newborns. The research involves advanced techniques in immunology to explore B cell biology and its implications for fetal development. Patients may benefit from insights that could lead to new therapies for pregnancy-related complications.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for ensuring healthier pregnancies and better outcomes for newborns.
How similar studies have gone: Previous research has shown promising results in understanding immune tolerance during pregnancy, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Erickson, John J. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Erickson, John J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.