How maternal and paternal X chromosomes interact in human biology and cancer
Official title: Competition between maternal and paternal X chromosomes in human biology and cancer
Funded at San Francisco State University · NIH-11060967 · Data updated 2026-11-12
This study looks at how the X chromosomes from mothers and fathers compete with each other and how this affects our health and cancer, with the hope of finding new ways to help people with aging-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Francisco State University NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 16, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $155,000 |
| NIH project number | 5R16GM149480-03 |
| Project ID | NIH-11060967 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with aging-related diseases or cancers that may be influenced by X chromosome biology.
✕Less likely to help
Patients with conditions unrelated to X chromosome dynamics or aging-related disorders may not receive benefit from this research.
What this research studies
This research investigates the competition between maternal and paternal X chromosomes and how this conflict affects human biology and cancer. By examining the regulatory networks and cellular impacts of this intragenomic conflict, the study aims to uncover the role of the X chromosome in health and disease. The researchers will analyze how these genetic interactions influence aging-related diseases and disorders, potentially leading to new intervention strategies. Patients may benefit from insights gained about the X chromosome's role in various health conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating aging-related diseases and cancers influenced by X chromosome dynamics.
How similar studies have gone: While the concept of intragenomic conflict is established in molecular evolution, this specific approach to studying X chromosome dynamics in relation to human health is relatively novel.
Where this research is happening
-
San Francisco State University
San Francisco, United States Active
Researchers
- Principal investigator: Roy, Scott — San Francisco State University
- Study coordinator: Roy, Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.