How maternal age affects the health and lifespan of offspring through mitochondrial mechanisms
Official title: Mitochondrial mechanisms of maternal age effects on offspring health and lifespan
Funded at Marine Biological Laboratory · NIH-11054593 · Data updated 2026-11-12
This study looks at how being an older mom might affect the health and lifespan of her children by examining tiny parts of cells called mitochondria, which can get damaged over time; the goal is to find out how these changes could impact kids and to discover ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marine Biological Laboratory NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project start | June 15, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $340,526 |
| NIH project number | 5R01AG076592-04 |
| Project ID | NIH-11054593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of advanced maternal age who are pregnant or planning to become pregnant.
✕Less likely to help
Patients who are younger mothers or those who are not planning to have children may not receive any benefit from this research.
What this research studies
This research investigates how advanced maternal age impacts the health and lifespan of offspring by focusing on mitochondrial mechanisms. It explores the role of mitochondria, which are inherited from the mother and can become damaged with age, in influencing the health of future generations. The study aims to identify specific mitochondrial changes that occur in older mothers and how these changes affect the development and aging of their offspring. By understanding these mechanisms, the research seeks to uncover potential interventions to improve offspring health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved health and longevity for children born to older mothers.
How similar studies have gone: Other research has indicated that mitochondrial dysfunction plays a significant role in aging, suggesting that this approach may yield valuable insights.
Where this research is happening
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Marine Biological Laboratory
Woods Hole, United States Active
Researchers
- Principal investigator: Gribble, Kristin — Marine Biological Laboratory
- Study coordinator: Gribble, Kristin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.