How mannose metabolism affects liver cell activation and fibrosis
Mannose metabolism as a regulator of hepatic stellate cell activation and fibrosis
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10932652
This study is looking at how sugar called mannose affects certain liver cells that can contribute to liver scarring, and it's for people dealing with liver issues like obesity, diabetes, or cancer, to see if adding mannose to their diet might help improve their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10932652 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mannose metabolism in the activation of hepatic stellate cells (HSCs), which are crucial in liver fibrosis. The study aims to understand how changes in mannose metabolism can influence HSC behavior, particularly in the context of liver diseases such as obesity, diabetes, and cancer. By examining the effects of mannose supplementation on HSC activation, the research seeks to identify potential therapeutic strategies for treating liver fibrosis. The approach includes both in vitro and in vivo experiments to gather comprehensive data on the relationship between mannose levels and liver cell function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with liver fibrosis related to conditions such as obesity, diabetes, or viral hepatitis.
Not a fit: Patients with liver fibrosis due to causes unrelated to mannose metabolism or those with advanced liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver fibrosis, improving outcomes for patients with liver diseases.
How similar studies have performed: While the specific role of mannose metabolism in HSC activation is relatively novel, related research has shown promising results in understanding metabolic pathways in liver diseases.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHU, JAIME C — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: CHU, JAIME C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer