How mannose metabolism affects liver cell activation and fibrosis
Mannose metabolism as a regulator of hepatic stellate cell activation and fibrosis
This study is looking at how sugar called mannose affects liver cells that can lead to scarring in the liver, which is important for people dealing with liver issues related to obesity, diabetes, or cancer, to find new ways to help treat liver fibrosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10763436 on NIH RePORTER |
What this research studies
This research investigates the role of mannose metabolism in the activation of hepatic stellate cells (HSCs), which are crucial in liver health and disease. The study aims to understand how changes in mannose metabolism can influence liver fibrosis, a condition where healthy liver tissue is replaced by scar tissue. By examining the effects of mannose on HSC activation, the research seeks to identify potential therapeutic strategies for treating liver fibrosis, particularly in patients with conditions like obesity, diabetes, and certain cancers. The approach includes both in vitro studies and analysis of human and animal models to gather comprehensive data on the relationship between mannose and liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with liver fibrosis, particularly those with underlying conditions such as obesity, diabetes, or certain cancers.
Not a fit: Patients with liver conditions unrelated to fibrosis or those who do not have metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver fibrosis, improving outcomes for patients with liver diseases.
How similar studies have performed: While the specific focus on mannose metabolism in HSCs is novel, related research has shown promising results in understanding metabolic pathways in liver diseases.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Chu, Jaime C — Icahn School of Medicine at Mount Sinai
- Study coordinator: Chu, Jaime C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.