How Male Germ Cells Develop and Reprogram Their Genes
DND1 Mediates Epigenetic Reprogramming During Cell Cycle Arrest In Male Germ Cells
This project looks at how male germ cells change their genetic instructions during a resting period, which is important for fertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11112328 on NIH RePORTER |
What this research studies
Before male germ cells become adult stem cells, their genetic programming undergoes significant changes. We want to understand if all germ cells change in the same way, or if only a special group does. We are also exploring how these genetic changes silence certain development pathways and help stabilize the future of these stem cells. Our work uses a specific protein called DND1 to help us identify different cell populations and understand their roles in this process.
Who could benefit from this research
Good fit: Patients interested in the fundamental biology of male fertility and germ cell development may find this research relevant.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions will not directly benefit from this basic science research.
Why it matters
Potential benefit: This work could help us better understand male fertility issues and conditions related to germ cell development, potentially leading to new ways to address them.
How similar studies have performed: While the general process of epigenetic reprogramming is known, the specific role of DND1 and the detailed mechanisms in distinct germ cell populations are novel aspects of this investigation.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Capel, Blanche — Duke University
- Study coordinator: Capel, Blanche
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.