How malaria parasites' mitochondria (their 'powerhouses') work
Mitochondrial Functions in Malaria Parasites
This work looks at how the energy-making parts of malaria parasites work to help guide development of better malaria medicines for people affected by the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11228401 on NIH RePORTER |
What this research studies
Researchers examine the mitochondria — the parts of malaria parasites that make energy — using parasite samples and laboratory models to see which mitochondrial functions are essential during the blood stage that makes people sick and which are only needed in mosquitoes. They analyze the parasite's unusual mitochondrial DNA and electron transport chain components to identify weak points. The team tests how current and experimental antimalarial drugs affect these mitochondrial targets. Laboratory methods include molecular genetics, biochemical assays, and parasite culture to link mitochondrial function with drug action and parasite survival.
Who could benefit from this research
Good fit: Ideal candidates would be people with confirmed malaria or individuals willing to provide blood samples through partnering clinics for research on parasite biology.
Not a fit: People without malaria or anyone seeking immediate clinical treatment are unlikely to receive direct benefit from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new or improved antimalarial drugs that more effectively kill parasites and slow drug resistance.
How similar studies have performed: Previous studies, including work by this group, have shown the parasite mitochondrion is a valid target for some approved antimalarials, though many mitochondrial functions remain underexplored.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Vaidya, Akhil B — Drexel University
- Study coordinator: Vaidya, Akhil B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.