How magnesium affects heart cell function during injury
Official title: Mitochondrial magnesium regulates MCU activity and PTP opening during ischemic reperfusion injury
Funded at Rowan University School/osteopathic Med · NIH-11026856 · Data updated 2026-11-12
This study looks at how magnesium helps heart cells stay healthy during times when blood flow is reduced and then restored, with the goal of finding new ways to protect your heart from damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University School/osteopathic Med NIH-funded |
| Lab location | 1 site (Stratford, United States) |
| Project start | January 20, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 1R01HL176747-01 |
| Project ID | NIH-11026856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that predispose them to ischemic heart injury, such as coronary artery disease or heart failure.
✕Less likely to help
Patients with non-cardiac conditions or those who do not experience ischemic events may not benefit from this research.
What this research studies
This research investigates the role of magnesium in heart cells, particularly during periods of injury caused by reduced blood flow and subsequent restoration. The study focuses on how magnesium regulates calcium uptake in mitochondria, which is crucial for heart cell survival and function. By examining the mechanisms of magnesium influx and its effects on heart cells under stress, the research aims to uncover potential therapeutic targets for improving heart health. Patients may benefit from insights gained about how to protect heart cells from damage during ischemic events.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart cells from damage during ischemic events, potentially reducing the risk of heart failure.
How similar studies have gone: Previous research has shown promising results regarding the role of magnesium in cardiac function, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Rowan University School/osteopathic Med
Stratford, United States Active
Researchers
- Principal investigator: Santhanam, Shanmughapriya — Rowan University School/osteopathic Med
- Study coordinator: Santhanam, Shanmughapriya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.