How macrophages respond to radiation exposure
Official title: RNA and DNA sensors in the response of macrophages to ionizing radiation
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11088734 · Data updated 2026-11-12
This study is looking at how radiation affects important immune cells called macrophages, which help control inflammation, to find new ways to treat inflammation caused by radiation exposure, so patients can have better options for managing their symptoms.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | May 15, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $199,469 |
| NIH project number | 5R21AI173847-02 |
| Project ID | NIH-11088734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to ionizing radiation and are experiencing related inflammatory conditions.
✕Less likely to help
Patients who have not been exposed to ionizing radiation or do not have inflammatory responses related to such exposure may not benefit from this research.
What this research studies
This research investigates how exposure to ionizing radiation affects macrophages, which are key immune cells involved in inflammation. The study focuses on understanding the signaling mechanisms that lead to the activation and polarization of these cells in response to radiation. By examining the role of specific DNA and RNA sensors, the research aims to identify potential therapeutic targets to manage inflammation caused by radiation exposure. Patients may benefit from insights that could lead to improved treatments for radiation-induced inflammatory conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing inflammation caused by radiation exposure.
How similar studies have gone: Previous research has shown success in understanding immune responses to radiation, but this specific approach focusing on RNA and DNA sensors is relatively novel.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Iordanskiy, Sergey — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Iordanskiy, Sergey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.