How macrophages affect heart muscle metabolism after a heart attack
Official title: Role of macrophages in regulating cardiac muscle metabolism
Funded at University of California Los Angeles · NIH-11022773 · Data updated 2026-11-12
This study is looking at how certain immune cells in the heart, called macrophages, affect heart health after a heart attack, with the goal of finding new ways to help people recover and improve heart function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $771,750 |
| NIH project number | 1R01HL176691-01 |
| Project ID | NIH-11022773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a myocardial infarction and are at risk for heart failure.
✕Less likely to help
Patients who have not had a heart attack or those with chronic heart conditions unrelated to myocardial infarction may not benefit from this research.
What this research studies
This research investigates the role of macrophages in the heart following a myocardial infarction, focusing on how these immune cells interact with cardiac muscle cells. The study aims to understand the mechanisms by which macrophages disrupt cardiac metabolism and contribute to heart function decline. By using advanced techniques such as bone marrow transplantation and monoclonal antibodies, the researchers hope to identify potential therapeutic strategies to improve heart function after injury. Patients may benefit from insights that could lead to new treatments for heart failure and recovery post-heart attack.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart function and recovery after a heart attack.
How similar studies have gone: Previous research has shown promising results in understanding immune cell interactions in heart injury, suggesting that this approach may yield significant insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Deb, Arjun — University of California Los Angeles
- Study coordinator: Deb, Arjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.