How macrophages affect healing after cochlear implants
Role of Macrophages on Tissue Remodeling Following Cochlear Implantation
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10853095
This study is looking at how certain materials in cochlear implants affect the healing process and the behavior of immune cells called macrophages, with the hope of making cochlear implants work better for patients by reducing complications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10853095 on ClinicalTrials.gov |
What this research studies
This research investigates the role of macrophages in the healing process following cochlear implantation. It aims to understand how the materials used in cochlear implants, such as platinum and silicone, trigger a foreign body response that can lead to fibrosis, which negatively impacts the device's performance. By using in vitro models, the study will explore how these materials influence macrophage behavior and how electrical stimulation may alter this response. The ultimate goal is to improve cochlear implant outcomes for patients by minimizing complications related to tissue remodeling.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are candidates for cochlear implantation, particularly those with significant residual hearing.
Not a fit: Patients who have already received cochlear implants and are not experiencing complications may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cochlear implant designs that enhance hearing outcomes for patients.
How similar studies have performed: Previous research has shown that understanding the immune response to biomaterials can lead to advancements in implant technology, indicating potential for success in this area.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HANSEN, MARLAN R — UNIVERSITY OF IOWA
- Study coordinator: HANSEN, MARLAN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.