How m6A modification of HIV RNA influences its processing
Official title: m6A Modification of HIV RNA Affects its Post-transcriptional Processing
Funded at Case Western Reserve University · NIH-10921550 · Data updated 2026-11-12
This study is looking at how a specific chemical change in HIV's genetic material affects how the virus makes copies of itself, which could help us find new ways to treat HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI183967-01 |
| Project ID | NIH-10921550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are interested in understanding the molecular mechanisms of their infection.
✕Less likely to help
Patients who are not infected with HIV or those who are in the late stages of AIDS may not benefit from this research.
What this research studies
This research investigates the role of m6A modification in the processing of different classes of HIV RNA transcripts. It focuses on understanding how these modifications affect the export and translation of unspliced and singly spliced HIV transcripts, which are crucial for the virus's replication. By examining the interactions between HIV RNA and host factors, including RNA binding proteins, the study aims to clarify the complex mechanisms that govern HIV gene expression. This could lead to new insights into HIV biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HIV infection and potentially developing new treatments.
How similar studies have gone: While there have been studies on m6A modification in HIV, this research aims to explore its effects in a novel way, focusing on post-transcriptional processing, which has not been extensively studied.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Honeycutt, Ethan — Case Western Reserve University
- Study coordinator: Honeycutt, Ethan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.