How lysosomal metabolism affects aging and Alzheimer's disease
Lysosomal NADPH metabolism regulates proteostasis, aging and tauopathy
This study is looking at how the way our cells break down and manage proteins affects aging and Alzheimer's disease, hoping to find new ways to help prevent or treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10883910 on NIH RePORTER |
What this research studies
This research investigates the role of lysosomal metabolism in maintaining protein balance (proteostasis) and its impact on aging and Alzheimer's disease (AD). By studying the cellular mechanisms in model organisms, the research aims to uncover how disruptions in lysosomal function contribute to the development of AD. The approach includes examining the signaling pathways between lysosomes and the endoplasmic reticulum, which are crucial for cellular health. The findings could lead to new insights into preventing or treating Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults at risk of developing Alzheimer's disease or those with early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or other severe neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by restoring proteostasis.
How similar studies have performed: Other research has shown promising results in understanding the role of cellular metabolism in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Dang, Weiwei — Baylor College of Medicine
- Study coordinator: Dang, Weiwei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.