How lymphocytes move through different tissue environments
Mechanisms of regulation of lymphocyte migration by actin cytoskeletal effectors
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-10891498
This study is looking at how immune cells called lymphocytes move through different tissues in the body to fight infections and inflammation, and it aims to understand the proteins that help them move, which could lead to new treatments for autoimmune diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10891498 on ClinicalTrials.gov |
What this research studies
This research investigates how lymphocytes, a type of immune cell, migrate through various tissue environments to effectively respond to infections and inflammation. The study focuses on understanding the role of specific proteins that regulate the cytoskeleton, which is crucial for cell movement. By using advanced imaging techniques, researchers will observe how these cells navigate through tight spaces and different adhesive conditions. The findings could provide insights into immune function and potential therapeutic targets for autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those interested in immune system function.
Not a fit: Patients with non-autoimmune conditions or those not involved in immune responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and enhance our understanding of immune responses.
How similar studies have performed: Previous research has shown success in understanding immune cell migration, making this approach both relevant and promising.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACOBELLI, JORDAN — UNIVERSITY OF COLORADO DENVER
- Study coordinator: JACOBELLI, JORDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.