How lymphatic transport is affected in inflammatory bowel disease
Mechanisms that alter lymphatic transport in inflammatory bowel disease
This study is looking at how the lymphatic system works differently in people with Crohn's disease, focusing on a specific protein that might affect how well this system functions, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11010832 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which lymphatic transport is altered in patients with inflammatory bowel disease, particularly Crohn's disease. It focuses on the role of B cell-expressed lymphotoxin and its signaling pathways in lymphatic function. By studying tissue samples from patients and using mouse models, the research aims to understand how lymphatic obstructions occur and their impact on disease progression. The findings could lead to new insights into the relationship between lymphatics and inflammation in Crohn's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease who are experiencing complications related to lymphatic transport.
Not a fit: Patients with inflammatory bowel disease who do not have significant lymphatic involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with inflammatory bowel disease by targeting lymphatic dysfunction.
How similar studies have performed: While the specific mechanisms being investigated are novel, there is existing research indicating that understanding lymphatic function can lead to advancements in treating inflammatory conditions.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Randolph, Gwendalyn J — Washington University
- Study coordinator: Randolph, Gwendalyn J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.