How lymphatic cells and immune cells work together to build strong protection
Cooperation between lymphatic stroma and hematopoietic cells shapes protective immunity
This project explores how our body's lymphatic system stores parts of viruses and vaccines to help our immune system remember and fight off future infections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11076811 on NIH RePORTER |
What this research studies
Our bodies can keep pieces of viruses and vaccines stored for a long time, even after an infection is gone. These stored pieces, called antigens, are held by special cells in our lymphatic system. This storage helps our immune system create stronger memory cells, which are better at clearing future infections. This project aims to understand exactly which cells and processes are involved in storing these antigens and how they lead to better protection from diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future applications could benefit individuals seeking improved vaccine efficacy.
Not a fit: Patients looking for immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to design vaccines that provide longer-lasting and more effective protection against infections.
How similar studies have performed: Previous work by this lab and others has shown that antigens can persist and contribute to enhanced immunity, providing a strong foundation for this deeper investigation.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Tamburini, Beth Ann — University of Colorado Denver
- Study coordinator: Tamburini, Beth Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.