How lung-resident immune cells control allergic inflammation and immune memory
Role of resident macrophages in type II responses and trained immunity
This work looks at how immune cells that live in the lungs influence allergic-type inflammation and lasting immune changes for people with asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11238971 on NIH RePORTER |
What this research studies
Researchers will focus on specialized lung-resident macrophages found near airways and nerves to understand their role in type 2 (allergic) inflammation and trained immunity. They will use experiments in mice alongside analysis of human lung and airway samples to map the cells' gene activity and signaling behavior. The team will observe how these macrophages interact with other immune cells and how altering them affects inflammation and tissue repair. Findings aim to connect basic cell biology to features of human asthma and point to possible intervention points.
Who could benefit from this research
Good fit: Ideal candidates for any human-participation components would be adults with allergic asthma or chronic airway inflammation who can provide sputum, blood, or consent to bronchoscopic sampling or tissue donation.
Not a fit: People without asthma or allergic airway disease, or those unable or unwilling to provide lung-related samples, are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could reveal new cellular pathways to reduce allergic airway inflammation and lead to better treatments for asthma.
How similar studies have performed: Previous animal and human tissue studies indicate lung macrophages shape allergic inflammation, but turning these findings into effective human therapies remains largely unproven.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Khanna, Kamal Mohan — New York University School of Medicine
- Study coordinator: Khanna, Kamal Mohan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.