How lung microbes affect breathing problems after stem-cell transplant
Microbiota Regulation of Pulmonary Complications Post-HCT
Looking at whether shifts in lung microbes after hematopoietic (stem cell) transplant link to lung injury in transplant patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11188971 on NIH RePORTER |
What this research studies
If you take part, researchers will collect lung samples and medical information from people who had hematopoietic cell transplants to see how the lung microbiome changes after transplant. They will use 16S rRNA sequencing to identify which bacteria are present and compare those patterns with lab animal models that recreate transplant-related lung injury. The team will also study how viral reactivation may interact with microbial changes to cause lung inflammation or fibrosis. Overall, the work is aimed at finding microbial patterns that could point to ways to prevent or treat post-transplant lung complications.
Who could benefit from this research
Good fit: People who have received hematopoietic (stem cell or bone marrow) transplants and are willing to provide lung samples and medical data would be ideal candidates.
Not a fit: People without a history of hematopoietic cell transplant, those with unrelated lung diseases, or those unwilling to provide samples are unlikely to benefit directly from this work.
Why it matters
Potential benefit: Could lead to new ways to prevent or treat serious lung complications after stem-cell transplant by targeting the lung microbiome.
How similar studies have performed: Previous studies have linked microbiome changes to worse outcomes after transplant and this team has shown associations, but turning those findings into proven treatments is still early and novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Zhou, Xiaofeng — University of Michigan at Ann Arbor
- Study coordinator: Zhou, Xiaofeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.