How lung immune cells make the anti-inflammatory protein IL-10
Transcriptional and metabolomic regulation of IL-10 in pulmonary ILC2s
This project looks for ways to increase IL‑10 production in lung immune cells to reduce allergy-driven airway inflammation in people with allergic asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11159527 on NIH RePORTER |
What this research studies
You would learn about a type of lung immune cell (ILC2) that can make the anti-inflammatory protein IL‑10 and how that helps calm allergic lung inflammation. The team will use advanced gene and chromatin sequencing and mouse models to study transcription factors like cMaf and Blimp‑1 and will manipulate these genes using retroviral methods and knockout mice. They will also test how cell metabolism—glycolysis, fatty acid oxidation, and AMPK signaling—affects IL‑10 production. The aim is to find molecular or metabolic targets that could eventually be used to reduce airway inflammation from allergies.
Who could benefit from this research
Good fit: People with allergic asthma or other allergic airway diseases driven by type‑2 inflammation would be the most relevant group for findings from this research.
Not a fit: People with non‑allergic asthma or airway problems not driven by type‑2 inflammation are less likely to benefit from the approaches studied here.
Why it matters
Potential benefit: If successful, this work could point to new ways to boost lung IL‑10 and reduce allergic airway inflammation and asthma symptoms.
How similar studies have performed: Other labs have confirmed the existence of IL‑10 producing ILC2s in animal models, but using transcriptional and metabolic targeting to boost IL‑10 is still early and largely preclinical.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Akbari, Omid — University of Southern California
- Study coordinator: Akbari, Omid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.