How lung immune cells and nerves interact during inflammation
Official title: Regulation of lung inflammation by crosstalk between dendritic cells and sensory neurons
Funded at Rutgers Biomedical and Health Sciences · NIH-10991021 · Data updated 2026-11-12
This study is looking at how certain immune cells in the lungs talk to nerve cells that react to allergens and germs, to better understand lung inflammation and potentially find new treatments for asthma and other breathing issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | November 21, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $190,141 |
| NIH project number | 5R21AI180678-02 |
| Project ID | NIH-10991021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from asthma or other allergic respiratory conditions.
✕Less likely to help
Patients with non-allergic respiratory issues or those without lung inflammation may not benefit from this research.
What this research studies
This research investigates the interaction between dendritic cells, which are key immune sensors in the lungs, and sensory neurons that respond to allergens and pathogens. By studying how these two components communicate, the research aims to understand their roles in lung inflammation, particularly in response to infections and allergies. The project uses a model of helminth infection to explore how these interactions influence immune responses and inflammation in the lungs. Patients may benefit from insights gained into new treatments for asthma and other respiratory conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing asthma and other allergic conditions.
How similar studies have gone: Other research has shown promising results in understanding immune responses in the lungs, making this approach a continuation of established findings.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Kumamoto, Yosuke — Rutgers Biomedical and Health Sciences
- Study coordinator: Kumamoto, Yosuke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.