How lung cells sense mechanical tension to regulate gas exchange surface
Official title: Mechanosensor Function in the Control of Gas Exchange Surface Size and Composition
Funded at University of California, San Diego · NIH-10916474 · Data updated 2026-11-12
This study is looking at how lung cells respond to the stretching that happens when we breathe, focusing on a special sensor called Piezo2, to help us learn more about lung growth and healing, which could lead to better treatments for lung problems related to stress on the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $555,136 |
| NIH project number | 5R01HL169853-02 |
| Project ID | NIH-10916474 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with lung conditions or those at risk of developing lung diseases, particularly related to mechanical stress.
✕Less likely to help
Patients with non-respiratory conditions or those whose lung function is not affected by mechanical tension may not benefit from this research.
What this research studies
This research investigates how alveolar epithelial cells in the lungs sense mechanical tension during breathing and how this affects the size and composition of the gas exchange surface. By studying a specific mechanosensor called Piezo2, the research aims to understand its role in lung development and injury repair. The approach includes examining the molecular feedback mechanisms triggered by mechanical forces, which could lead to better insights into lung health and disease. Patients may benefit from findings that improve understanding of lung conditions related to mechanical stress.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating lung diseases by enhancing the repair and regeneration of lung tissue.
How similar studies have gone: Other research has shown promising results in understanding mechanosensation in various tissues, suggesting potential for success in this area as well.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Sun, Xin — University of California, San Diego
- Study coordinator: Sun, Xin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.