How lung cells respond to mechanical strain for better lung health
Official title: Mechanical signaling through the nuclear membrane in lung alveolar health
Funded at University of Pennsylvania · NIH-11095890 · Data updated 2026-11-12
This study looks at how the tiny cells in your lungs react when you breathe and how they work together, which could help us understand lung problems like acute lung injury and improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $790,778 |
| NIH project number | 5R01HL168803-03 |
| Project ID | NIH-11095890 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be experiencing or at risk for acute lung injury.
✕Less likely to help
Patients with chronic lung conditions unrelated to acute lung injury may not receive direct benefits from this research.
What this research studies
This research investigates how lung cells, particularly those in the alveoli, respond to the mechanical strain caused by breathing. It focuses on the interactions between different cell types in the lungs and how these interactions can affect cell identity and function. By using advanced genetic and biophysical techniques, the study aims to understand how the loss of certain cell functions can lead to changes in lung health. Patients may benefit from insights gained about lung cell behavior in conditions like acute lung injury.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving lung health and treating conditions like acute lung injury.
How similar studies have gone: Other research has shown promising results in understanding cell behavior under mechanical strain, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Morrisey, Edward E — University of Pennsylvania
- Study coordinator: Morrisey, Edward E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.