How lung cells respond after injury in premature infants
Transcriptional Regulation of Endothelial Cells after Neonatal Lung Injury
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-10929949
This study is looking at how lung injuries in premature babies can lead to breathing problems and is testing new ways to help their lungs heal better by using tiny particles to deliver helpful genes, with the goal of improving their lung health and breathing.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10929949 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of neonatal lung injury, particularly in preterm infants who may develop Bronchopulmonary Dysplasia (BPD). It focuses on understanding how endothelial cells, which line blood vessels in the lungs, are regulated after injury and how this impacts lung development and function. The researchers are exploring innovative therapies using nanoparticles to deliver genes that promote blood vessel growth in the lungs, aiming to improve respiratory outcomes for affected infants. By studying specific cell types involved in lung repair, the research seeks to identify new treatment strategies for enhancing lung health in premature babies.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who are at risk of developing Bronchopulmonary Dysplasia due to neonatal lung injury.
Not a fit: Patients who are not premature or do not have lung injury-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve lung function and reduce complications in premature infants suffering from BPD.
How similar studies have performed: Other research has shown promise in using gene therapy and cell transplantation to improve lung function in similar conditions, indicating that this approach could be effective.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KALINICHENKO, VLADIMIR — UNIVERSITY OF ARIZONA
- Study coordinator: KALINICHENKO, VLADIMIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway Disease