How lung cells influence immune cell behavior in lung injuries
Endothelial Instruction of Macrophage Fate in Inflammatory Lung Injury
['FUNDING_P01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10895355
This study is looking at how lung cells talk to immune cells during lung injuries to figure out how these immune cells can help heal the lungs and get them back to normal.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10895355 on ClinicalTrials.gov |
What this research studies
This research investigates how endothelial cells in the lungs communicate with macrophages, a type of immune cell, during acute lung injury. It aims to understand the signals that guide monocytes, which are precursors to macrophages, to transition into tissue-resident macrophages that help repair lung damage. By exploring the mechanisms of this interaction, the study seeks to uncover how these macrophages can promote healing and restore normal lung function. The research employs advanced techniques to analyze the changes in macrophage behavior and characteristics in response to signals from endothelial cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing acute lung injury or related pulmonary conditions.
Not a fit: Patients with chronic lung diseases or those who are not experiencing acute lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to repair lung injuries and improve recovery outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding macrophage behavior in other inflammatory conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REHMAN, JALEES — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: REHMAN, JALEES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury