How lung cell factors can improve lung cancer treatment
Immunoregulatory role of lung-resident club cell factors in lung cancer
This study is looking at how certain lung cells can help make cancer treatments work better for people with non-small cell lung cancer by using a combination of low-dose radiation and immune therapy, with the goal of improving patient outcomes and survival rates.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11017770 on NIH RePORTER |
What this research studies
This research investigates the role of lung-resident club cell factors in enhancing the effectiveness of immune checkpoint inhibitors for treating non-small cell lung cancer (NSCLC). The study focuses on understanding how these factors can inhibit immunosuppressive cells in the tumor microenvironment, which often hinder treatment success. By combining low-dose radiation therapy with immune checkpoint inhibitors, the research aims to activate specific lung cell secretions that may lead to better patient outcomes. The approach includes analyzing patient responses to treatment and identifying biomarkers that correlate with improved survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who are undergoing treatment with immune checkpoint inhibitors.
Not a fit: Patients with other types of lung cancer or those who are not receiving immune checkpoint inhibitors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lung cancer, potentially improving survival rates for patients.
How similar studies have performed: Previous research has shown promising results in enhancing cancer treatment efficacy through similar approaches, indicating potential for success in this study.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Mittal, Vivek — Weill Medical Coll of Cornell Univ
- Study coordinator: Mittal, Vivek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.