How LRRK2 activity in immune cells affects gut health in Crohn's disease
Official title: Macrophage LRRK2 activity regulates gut epithelial homeostasis
Funded at Washington University · NIH-10983397 · Data updated 2026-11-12
This study is looking at how a gene called LRRK2 affects gut health and inflammation in people with Crohn's disease, especially those with certain genetic traits, to find new ways to help improve their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $429,180 |
| NIH project number | 1R01DK138465-01A1 |
| Project ID | NIH-10983397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's disease, particularly those with specific genetic risk factors related to LRRK2.
✕Less likely to help
Patients without Crohn's disease or those who do not carry the relevant genetic risk factors may not benefit from this research.
What this research studies
This research investigates the role of LRRK2, a gene linked to both Crohn's disease and Parkinson's disease, in regulating gut health. It focuses on how LRRK2 hyperactivity in macrophages, a type of immune cell, contributes to inflammation and defects in gut epithelial cells, particularly in patients with specific genetic risk factors. By understanding these mechanisms, the research aims to identify new therapeutic strategies for Crohn's disease that could improve patient outcomes. The study will involve analyzing genetic interactions and environmental factors that influence LRRK2 activity in the gut.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage Crohn's disease and improve the quality of life for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of LRRK2 in other diseases, indicating potential for success in this novel approach to Crohn's disease.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Liu, Ta-Chiang — Washington University
- Study coordinator: Liu, Ta-Chiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.