How LRP1 controls neural stem cell behavior after stroke
LRP1 as a novel regulator of CXCR4 in adult neural stem cells and post-stroke response
This project looks at whether changing a protein called LRP1 can help brain stem cells move to damaged areas and support recovery after an ischemic stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11378858 on NIH RePORTER |
What this research studies
From a patient's perspective: scientists found that a protein called LRP1 may change how adult neural stem cells respond after a stroke by altering a signaling receptor called CXCR4. To study this, they removed LRP1 in adult neural stem cells in mice and used a common stroke model to see how cells migrate, how large the injury becomes, and how well the animals recover. The team will dig into the molecular signals linking LRP1 to CXCR4 and test whether manipulating this pathway can improve stem-cell–related repair. Although much of the work is in animals, the goal is to inform future treatments that harness or guide stem cells to aid recovery in people who have had ischemic strokes.
Who could benefit from this research
Good fit: Adults who have experienced an ischemic (blood-flow) stroke and who might be interested in future stem-cell–based recovery approaches or in donating samples for research could be relevant for follow-up studies.
Not a fit: People seeking an immediate treatment today, or those with hemorrhagic (bleeding) stroke or unrelated neurologic conditions, are unlikely to benefit directly from this preclinical project.
Why it matters
Potential benefit: If successful, this work could point to new ways to boost stem-cell–driven repair after stroke and potentially improve recovery and reduce long-term disability.
How similar studies have performed: Previous research shows neural stem cells and the chemokine receptor CXCR4 help direct cells to stroke lesions, but the role of LRP1 in controlling CXCR4 is largely novel and has not yet been tested in people.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Sayre, Naomi Ledene — University of Texas Hlth Science Center
- Study coordinator: Sayre, Naomi Ledene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.