How low thiamine levels affect brain function and Alzheimer's disease
Official title: Implications of Metabolic Dysfunction during Thiamine Insufficiency
Funded at University of Georgia · NIH-10982455 · Data updated 2026-11-12
This study is looking at how low levels of vitamin B1 (thiamine) might affect thinking and memory, especially in people at risk for Alzheimer's disease, to find out if boosting thiamine could help keep our brains healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $331,600 |
| NIH project number | 5R01AG076625-03 |
| Project ID | NIH-10982455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing cognitive decline or diagnosed with Alzheimer's disease, particularly those with low thiamine levels.
✕Less likely to help
Patients who are not experiencing cognitive issues or do not have any metabolic dysfunction related to thiamine may not benefit from this research.
What this research studies
This research investigates the impact of low thiamine (vitamin B1) levels on cognitive function and its potential role in the development of Alzheimer's disease. It focuses on understanding how thiamine deficiency leads to metabolic dysfunction in the brain, which may contribute to energy deficits, inflammation, and the formation of plaques associated with Alzheimer's. The study aims to explore the mechanisms behind these changes and their correlation with cognitive decline, using both laboratory models and patient data. By examining these relationships, the research seeks to provide insights into potential therapeutic strategies for improving brain health.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that improve cognitive function and slow the progression of Alzheimer's disease in patients with thiamine deficiency.
How similar studies have gone: Previous research has indicated a link between thiamine deficiency and cognitive decline, suggesting that this approach may yield valuable insights, although the specific mechanisms are still being explored.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Zastre, Jason a — University of Georgia
- Study coordinator: Zastre, Jason a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.