How low oxygen levels affect the tumor environment in pancreatic cancer
Role of Hypoxia in Shaping the Tumor Stroma in Pancreatic Cancer
This study looks at how low oxygen levels in pancreatic cancer affect the behavior of cancer cells and nearby healthy cells, with the hope of finding new ways to improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11089567 on NIH RePORTER |
What this research studies
This research investigates the role of low oxygen levels, or hypoxia, in shaping the tumor environment of pancreatic cancer. It focuses on how hypoxia influences the behavior of both cancer cells and surrounding non-cancerous cells, such as fibroblasts and immune cells. By examining the interactions between these cells in a low-oxygen setting, the study aims to uncover mechanisms that contribute to tumor growth and resistance to treatment. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma, particularly those experiencing advanced disease.
Not a fit: Patients with early-stage pancreatic cancer or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown that targeting tumor-stroma interactions in other cancers can lead to significant treatment advancements, suggesting potential for success in this area as well.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Lee, Kyoung Eun — University of Michigan at Ann Arbor
- Study coordinator: Lee, Kyoung Eun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.