How low oxygen levels affect the development of the eye lens
Official title: Hypoxia regulation of the lens
Funded at Florida Atlantic University · NIH-11062983 · Data updated 2026-11-12
This study looks at how low oxygen levels during eye lens development affect the growth and function of lens cells, helping us understand how these conditions keep the lens clear and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project start | August 1, 2019 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $381,250 |
| NIH project number | 2R01EY029708-06 |
| Project ID | NIH-11062983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals with a family history of lens disorders or those experiencing early signs of lens-related issues.
✕Less likely to help
Patients with fully developed and healthy lenses or those with unrelated ocular conditions may not benefit from this research.
What this research studies
This research investigates how the lack of oxygen during the development of the eye lens influences the formation and function of lens cells. It focuses on the unique hypoxic environment that lens cells experience and how this low oxygen level triggers the expression of essential genes necessary for lens maturation. By studying the mechanisms involved, the research aims to uncover the role of specific transcription factors and regulatory pathways that are activated under these conditions. The findings could provide insights into the processes that ensure the lens maintains its transparency and structure.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lens-related disorders, such as cataracts.
How similar studies have gone: Previous studies have shown that understanding the role of hypoxia in cellular development can lead to significant advancements in treating related conditions, suggesting potential success for this approach.
Where this research is happening
-
Florida Atlantic University
Boca Raton, United States Active
Researchers
- Principal investigator: Kantorow, Marc — Florida Atlantic University
- Study coordinator: Kantorow, Marc
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.