How low oxygen levels affect immune cell behavior in pancreatic cancer
Official title: Hypoxic regulation of macrophage migration and function via fibroblast reprogramming in pancreatic cancer
Funded at University of Michigan at Ann Arbor · NIH-10929976 · Data updated 2026-11-12
This study is looking at how low oxygen levels in pancreatic cancer affect immune cells, especially those that help fight the cancer, to find out how they interact with other cells in the tumor and discover new ways to improve treatment.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,094 |
| NIH project number | 5F31CA281194-02 |
| Project ID | NIH-10929976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma who are experiencing treatment resistance.
✕Less likely to help
Patients with other types of cancer or those not diagnosed with pancreatic cancer may not benefit from this research.
What this research studies
This research investigates how low oxygen levels in pancreatic cancer influence the behavior of immune cells, particularly macrophages. It focuses on understanding the interactions between these immune cells and cancer-associated fibroblasts in the tumor environment. By studying how hypoxia affects these cells, the research aims to uncover new mechanisms that contribute to cancer progression and resistance to treatment. The approach includes using animal models to observe changes in cell behavior in response to low oxygen conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance immune response against pancreatic cancer.
How similar studies have gone: Previous research has shown that targeting the tumor microenvironment can improve treatment outcomes in various cancers, suggesting potential success for this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Hannifin, Sean Matthew — University of Michigan at Ann Arbor
- Study coordinator: Hannifin, Sean Matthew
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.