How low oxygen levels affect fibroblast behavior in pancreatic cancer
Official title: Role of hypoxia in fibroblast reprogramming in pancreatic cancer
Funded at University of Michigan at Ann Arbor · NIH-10992594 · Data updated 2026-11-12
This study is looking at how low oxygen levels in pancreatic cancer might change the behavior of certain cells that help tumors grow, which could help us find new ways to treat the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,094 |
| NIH project number | 5F31CA284520-02 |
| Project ID | NIH-10992594 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma (PDAC), particularly those with advanced disease.
✕Less likely to help
Patients with early-stage pancreatic cancer or those with other types of cancer may not benefit from this research.
What this research studies
This research investigates the role of low oxygen levels, or hypoxia, in the behavior of fibroblasts within pancreatic cancer. It focuses on understanding how hypoxia influences the formation of inflammatory cancer-associated fibroblasts (iCAFs) and their interactions with pancreatic tumor cells. By using 3D cocultures of these cells, researchers aim to uncover the mechanisms by which hypoxia affects tumor progression and resistance to treatment. This could lead to new insights into the tumor microenvironment and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for pancreatic cancer by targeting the tumor microenvironment.
How similar studies have gone: Other research has shown promising results in understanding the tumor microenvironment in various cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Ngodup, Tenzin — University of Michigan at Ann Arbor
- Study coordinator: Ngodup, Tenzin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.