How low oxygen levels affect fat metabolism in breast cancer linked to obesity
Official title: Impact of hypoxia on lipid metabolism in obesity-driven breast cancer progression
Funded at Purdue University · NIH-10980421 · Data updated 2026-11-12
This study is looking at how being overweight affects breast cancer and how low oxygen levels in the body might change the way fat behaves in cancer cells, with the hope of finding new treatment options that could help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | December 28, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $641,634 |
| NIH project number | 5R01CA271597-03 |
| Project ID | NIH-10980421 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast cancer who also have obesity.
✕Less likely to help
Patients with breast cancer who do not have obesity or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates how obesity influences the progression of breast cancer, particularly focusing on the effects of low oxygen levels (hypoxia) on fat metabolism. The study aims to understand the molecular mechanisms behind increased fat accumulation in cancer cells and how this relates to worse patient outcomes. By examining specific genes and proteins involved in fat synthesis and breakdown, the research seeks to uncover how these processes are altered in the presence of obesity and hypoxia. Patients may benefit from insights that could lead to new treatment strategies targeting lipid metabolism in breast cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve outcomes for breast cancer patients with obesity.
How similar studies have gone: Other research has shown promising results in understanding the role of lipid metabolism in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Teegarden, Dorothy — Purdue University
- Study coordinator: Teegarden, Dorothy
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.