How low oxygen levels affect blood stem cells under stress
Official title: Hypoxia's role in regulating stressed hematopoietic stem cells
Funded at Indiana University Indianapolis · NIH-11042199 · Data updated 2026-11-12
This study is looking at how low oxygen levels affect blood stem cells in the bone marrow, which could help improve treatments for conditions like bone marrow failure and certain cancers, making blood stem cell transplants and gene therapies more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | March 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $615,543 |
| NIH project number | 5R01DK139505-02 |
| Project ID | NIH-11042199 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with blood disorders such as Fanconi Anemia or those requiring hematopoietic stem cell transplantation.
✕Less likely to help
Patients with conditions unrelated to blood stem cell function or those not requiring transplantation may not benefit from this research.
What this research studies
This research investigates the impact of low oxygen levels on hematopoietic stem cells (HSCs) found in the bone marrow, particularly how these cells respond to stress. The study aims to understand the differences in HSC function when exposed to normal oxygen conditions versus higher oxygen levels typically used in laboratory settings. By examining these responses, the research seeks to uncover the molecular mechanisms that could enhance the effectiveness of blood stem cell transplants and gene therapies for various diseases. Patients may benefit from improved treatment strategies for conditions like bone marrow failure and certain cancers.
Why it matters
Potential benefit: If successful, this research could lead to more effective blood stem cell transplants and therapies for patients with blood disorders.
How similar studies have gone: Previous research has shown promising results in understanding the effects of oxygen levels on stem cells, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Kapur, Reuben — Indiana University Indianapolis
- Study coordinator: Kapur, Reuben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.