How low oxygen levels affect blood stem cells under stress
Hypoxia's role in regulating stressed hematopoietic stem cells
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11042199
This study is looking at how low oxygen levels affect blood stem cells in the bone marrow, which could help improve treatments for conditions like bone marrow failure and certain cancers, making blood stem cell transplants and gene therapies more effective for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11042199 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of low oxygen levels on hematopoietic stem cells (HSCs) found in the bone marrow, particularly how these cells respond to stress. The study aims to understand the differences in HSC function when exposed to normal oxygen conditions versus higher oxygen levels typically used in laboratory settings. By examining these responses, the research seeks to uncover the molecular mechanisms that could enhance the effectiveness of blood stem cell transplants and gene therapies for various diseases. Patients may benefit from improved treatment strategies for conditions like bone marrow failure and certain cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with blood disorders such as Fanconi Anemia or those requiring hematopoietic stem cell transplantation.
Not a fit: Patients with conditions unrelated to blood stem cell function or those not requiring transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective blood stem cell transplants and therapies for patients with blood disorders.
How similar studies have performed: Previous research has shown promising results in understanding the effects of oxygen levels on stem cells, indicating that this approach has potential for significant advancements.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAPUR, REUBEN — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: KAPUR, REUBEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.