How low GAS7 levels and high MYCN levels affect neuroblastoma spread
Official title: Interplay between low levels of GAS7 expression and MYCN overexpression and its impact on neuroblastoma metastasis
Funded at Mayo Clinic Rochester · NIH-10877719 · Data updated 2026-11-12
This study is looking at how two specific genes are connected in neuroblastoma, a type of cancer that affects kids, to find new ways to help treat children with this illness better and more safely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 15, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $345,528 |
| NIH project number | 5R01CA240323-05 |
| Project ID | NIH-10877719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with neuroblastoma, particularly those with MYCN amplification and advanced-stage disease.
✕Less likely to help
Patients with neuroblastoma who do not have MYCN amplification or those with early-stage disease may not benefit from this research.
What this research studies
This research investigates the relationship between low levels of the GAS7 gene and high levels of the MYCN oncogene in neuroblastoma, a common childhood cancer. By analyzing genetic data from patients and using zebrafish models, the study aims to understand how these genetic factors contribute to the spread of neuroblastoma. The goal is to uncover new mechanisms that could lead to safer and more effective treatments for children with advanced neuroblastoma. Patients may benefit from insights that could improve treatment strategies and outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for children with high-risk neuroblastoma.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing neuroblastoma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Zhu, Shizhen — Mayo Clinic Rochester
- Study coordinator: Zhu, Shizhen
Related research
Other NIH-funded projects on the same topics.
-
Understanding how B7-H3 contributes to neuroblastoma spread and immune evasion
This study is looking at a protein called B7-H3 that is often found in high amounts in neuroblastoma, a cancer that mainly affects kids, to see how it helps the cancer grow and avoid the immune system, with the goal of finding new ways to treat patients better.
-
Lymph node metastasis and immune tolerance in head and neck cancer
A study in people with head and neck cancer looks at how cancer spread to lymph nodes may shape the immune system and help tumors grow.
-
Targeting how RMS cells fail to mature to slow or stop pediatric muscle cancer spread
A project to understand why a pediatric muscle cancer called rhabdomyosarcoma spreads, and to test ideas that could slow or stop it by helping cancer cells mature properly.
-
Centers studying how cancer spreads through the body
A multi-institutional project at Rockefeller University is exploring how nerves, blood vessels, lymphatics, immune cells, and metabolites influence the spread of cancer to help identify new ways to stop metastasis.
-
Angiopoietin-2 and Tie2 signals shaping liver metastasis in pancreatic neuroendocrine tumors
A study explores how Angiopoietin-2 and the Tie2 receptor influence the spread of pancreatic neuroendocrine tumors to the liver and how this affects responses to immunotherapy.
-
Nanoparticles that boost MRI to find tiny brain metastases
This uses tiny magnetic nanoparticles and new MRI image processing to help doctors find very small brain metastases earlier in people with cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.