How low GAS7 levels and high MYCN levels affect neuroblastoma spread
Interplay between low levels of GAS7 expression and MYCN overexpression and its impact on neuroblastoma metastasis
This study is looking at how two specific genes are connected in neuroblastoma, a type of cancer that affects kids, to find new ways to help treat children with this illness better and more safely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10877719 on NIH RePORTER |
What this research studies
This research investigates the relationship between low levels of the GAS7 gene and high levels of the MYCN oncogene in neuroblastoma, a common childhood cancer. By analyzing genetic data from patients and using zebrafish models, the study aims to understand how these genetic factors contribute to the spread of neuroblastoma. The goal is to uncover new mechanisms that could lead to safer and more effective treatments for children with advanced neuroblastoma. Patients may benefit from insights that could improve treatment strategies and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neuroblastoma, particularly those with MYCN amplification and advanced-stage disease.
Not a fit: Patients with neuroblastoma who do not have MYCN amplification or those with early-stage disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for children with high-risk neuroblastoma.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing neuroblastoma, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Zhu, Shizhen — Mayo Clinic Rochester
- Study coordinator: Zhu, Shizhen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.