How long-term environmental exposures affect asthma risk
Multiple long-term environmental exposures and incidence of asthma
This project explores how long-term exposure to several environmental factors might raise the chance of developing asthma in people of different ages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11323868 on NIH RePORTER |
What this research studies
This project follows people from large U.S. cohorts (the Nurses’ Health Studies, Health Professionals Follow-Up Study, and Growing Up Today Study) and links their health information to long-term environmental data. Researchers will use participants' residential histories and public exposure maps for air pollution and other environmental factors to estimate decades of exposure. They will examine how combinations of exposures at different life stages relate to new cases of asthma using advanced statistical methods to separate multiple effects. If you are in one of these cohorts, you would contribute by answering questionnaires and allowing researchers to use your address and health records rather than trying new medications.
Who could benefit from this research
Good fit: Ideal candidates are U.S. residents enrolled (or eligible) in these long-term cohorts—typically adolescents through adults—who can share residential history and health information and do not already have asthma.
Not a fit: People seeking new asthma treatments or those with severe, long-standing asthma are unlikely to get direct clinical benefit from participation.
Why it matters
Potential benefit: If successful, this work could point to which environmental combinations increase asthma risk and guide prevention efforts and policy to reduce those exposures.
How similar studies have performed: Prior studies have linked air pollution and some other single exposures to asthma, but combining multiple long-term exposures across decades is a newer and less-tested approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hart, Jaime Elizabeth — Brigham and Women's Hospital
- Study coordinator: Hart, Jaime Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.