How long noncoding RNAs help balance X chromosome genes
Elucidating the molecular basis of lncRNA evolution for mammalian dosage compensation
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11158637
This work looks at how long noncoding RNAs evolved to switch off one X chromosome in females to help people affected by X-linked developmental conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11158637 on ClinicalTrials.gov |
What this research studies
The team studies a cluster of long noncoding RNA (lncRNA) genes that control X-inactivation across mammals. They compare DNA and RNA sequences across species and use CRISPR and other molecular lab techniques in model systems to test how these RNAs gained new functions. Experiments will measure how changes in those RNAs affect gene expression and development. Results aim to explain how RNA-based mechanisms arose and how they relate to human development and X-linked disorders.
Who could benefit from this research
Good fit: People with X-linked genetic conditions, family members of affected individuals, or volunteers willing to donate tissue, blood, or cell samples for research would be most relevant to this work.
Not a fit: Patients seeking immediate treatment or direct clinical benefit are unlikely to gain direct help because the project is basic laboratory research.
Why it matters
Potential benefit: If successful, this research could improve understanding of X-linked developmental disorders and guide future diagnostic or therapeutic approaches.
How similar studies have performed: Past work has shown lncRNAs such as XIST control X-inactivation, but the evolutionary origins and functional conversion of many lncRNAs remain largely novel and underexplored.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, SHA — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SUN, SHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.