How long non‑coding RNAs affect heart development and disease
lncRNA Function and Mechanisms during Cardiac Development and Disease
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11312591
This research tests whether certain long non‑coding RNAs change how heart cells grow, survive, and remodel in people with heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11312591 on ClinicalTrials.gov |
What this research studies
The team studies long non‑coding RNAs found in hearts from patients with ischemic cardiomyopathy and other cardiac conditions to understand their roles in cell growth, death, and remodeling. They focus on a specific RNA called lincRNA‑p21 and use gene expression analyses from patient heart tissue alongside laboratory models to see how it works. The group will manipulate these RNAs in lab-grown heart cells and in animal models using AAV9 viral delivery to observe effects on heart structure and function. Findings aim to point to RNA targets that could be changed to slow or reverse harmful heart remodeling.
Who could benefit from this research
Good fit: Ideal candidates would include people with ischemic cardiomyopathy or other forms of heart failure who can provide tissue samples or participate in related clinical sampling at the study site.
Not a fit: People without heart disease or those seeking an immediate treatment will unlikely receive direct personal benefit from this basic and translational research.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets that lead to therapies reducing heart cell death and harmful remodeling in heart disease.
How similar studies have performed: Prior laboratory studies have shown lncRNAs like lincRNA‑p21 influence cell proliferation and vascular remodeling, but applying these findings to human heart disease and therapies is still early and not yet proven in patients.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, DA-ZHI — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: WANG, DA-ZHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.