How long non-coding RNAs help activate genes
Structural and Functional Studies of lncRNAs in Gene Activation
['FUNDING_R01'] · DREXEL UNIVERSITY · NIH-11290347
Researchers are learning how certain long RNAs turn genes on in ways that could help people with cancers linked to these RNAs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DREXEL UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11290347 on ClinicalTrials.gov |
What this research studies
Scientists will study long non-coding RNAs, focusing on one called lncTCF7, to understand how they promote gene activation. In the lab they will map RNA structures and use biochemical tests to see how these RNAs bind and work with chromatin-remodeling proteins like the SWI/SNF complex. They will use cell-based models and molecular assays to observe changes in gene activity and protein interactions. The project aims to clarify how these RNAs contribute to normal gene control and to cancer when SWI/SNF components are mutated.
Who could benefit from this research
Good fit: This grant does not enroll patients; its findings are most relevant to people with cancers involving mutations in SWI/SNF or related gene-activation pathways.
Not a fit: Patients with conditions unrelated to gene regulation or cancers not involving lncRNAs or SWI/SNF are unlikely to see direct benefit from this basic lab research.
Why it matters
Potential benefit: If successful, the work could point to new biomarkers or therapeutic targets for cancers driven by faulty gene activation.
How similar studies have performed: Prior work shows lncRNAs can guide epigenetic regulators and some lncRNA–SWI/SNF interactions have been reported, but detailed structural and functional mechanisms remain largely unproven.
Where this research is happening
PHILADELPHIA, UNITED STATES
- DREXEL UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOMAROWTHU, SRINIVAS — DREXEL UNIVERSITY
- Study coordinator: SOMAROWTHU, SRINIVAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.