How long non-coding RNAs affect brain immune responses
Regulation of the Microglial Neuroimmune Response by Long Non-Coding RNAs
This study is looking at how certain RNA molecules help brain cells called microglia respond to inflammation, which could lead to new ways to understand and treat conditions like multiple sclerosis.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10514892 on NIH RePORTER |
What this research studies
This research investigates the role of long non-coding RNAs in regulating the immune responses of microglia, which are crucial cells in the brain's defense system. By examining how these RNA molecules influence microglial behavior during inflammation caused by infections, the study aims to uncover mechanisms that could either protect or harm brain cells. The approach involves analyzing gene expression changes in microglia in response to various stimuli, which may lead to new insights into neurodegenerative diseases like multiple sclerosis. Patients may benefit from a better understanding of how inflammation affects brain health and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative conditions, particularly those experiencing inflammation due to infections.
Not a fit: Patients with non-neurodegenerative conditions or those not experiencing inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance neuroprotection and reduce neurotoxicity in patients with neurodegenerative diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of non-coding RNAs in inflammation and neurodegeneration, suggesting that this approach may yield valuable insights.
Where this research is happening
Omaha, United States
- Creighton University — Omaha, United States (Active)
Researchers
- Principal investigator: Shibata, Annemarie — Creighton University
- Study coordinator: Shibata, Annemarie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.