How local vitamin D production affects chronic inflammation in cardiovascular disease
Contribution of nonrenal calcitriol production in chronic inflammation
This study is looking at how vitamin D made by immune cells might help reduce inflammation in atherosclerosis, a heart condition, using a special mouse model to find new ways to treat this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10874386 on NIH RePORTER |
What this research studies
This research investigates the role of locally produced vitamin D, specifically calcitriol, in reducing inflammation associated with atherosclerosis, a serious cardiovascular condition. The study utilizes a unique mouse model that lacks the normal kidney production of calcitriol, allowing researchers to focus on the effects of vitamin D produced by immune cells like macrophages. By examining how this local production influences inflammation and disease progression, the research aims to uncover new therapeutic strategies for managing atherosclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic inflammation or atherosclerosis who may benefit from enhanced vitamin D activity.
Not a fit: Patients without chronic inflammation or those not affected by cardiovascular diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that harness the anti-inflammatory properties of vitamin D to improve cardiovascular health.
How similar studies have performed: While the specific approach of examining local vitamin D production in this context is novel, previous studies have shown that vitamin D has anti-inflammatory effects, suggesting potential for success.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Meyer, Mark B — University of Wisconsin-Madison
- Study coordinator: Meyer, Mark B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.