How liver receptors affect obesity and metabolism
Hepatic Aryl Hydrocarbon Receptor Regulation of Obesity: Mechanisms of Action
This study is looking at how a specific protein in the body affects weight and metabolism, especially in female mice, to find new ways to help people struggling with obesity and related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10870226 on NIH RePORTER |
What this research studies
This research investigates the role of the Aryl Hydrocarbon Receptor (AhR) in regulating obesity and metabolic health, particularly focusing on how it influences the expression of a protein called fibroblast growth factor 21 (FGF21) in the liver. The study uses genetically modified mice to explore how the absence of AhR affects weight gain and metabolism, especially in females. By understanding these mechanisms, the research aims to identify new therapeutic strategies for treating obesity and related metabolic disorders. The findings could lead to innovative treatments that target metabolic pathways influenced by AhR and FGF21.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or metabolic disorders, particularly those who may benefit from novel therapeutic approaches.
Not a fit: Patients who do not have obesity or metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for obesity and metabolic disorders, improving health outcomes for affected patients.
How similar studies have performed: While there has been some research into FGF21-based therapies, this specific approach focusing on AhR regulation is relatively novel and has not been extensively tested.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Wright, Casey W — University of Texas Med Br Galveston
- Study coordinator: Wright, Casey W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.