How liver cells communicate and organize themselves
Cell-cell adhesion-mediated signaling determines epithelial polarization in the liver
This study is looking at how liver cells work together and stay organized, which is important for their job of moving substances like bile and proteins, and it hopes to find new ways to help improve treatments for liver diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10889040 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which liver cells, specifically hepatocytes and bile duct cells, achieve their unique structural organization and function. It focuses on the role of cell-cell adhesion and signaling in determining the polarity of these cells, which is crucial for their ability to transport substances like bile and proteins. By understanding these processes, the research aims to fill gaps in knowledge about liver cell function and its implications for liver diseases. Patients may benefit from insights that could lead to improved treatments for liver conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with liver diseases or conditions affecting liver function.
Not a fit: Patients with non-liver related health issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for liver diseases.
How similar studies have performed: Other research has shown success in understanding cell signaling and adhesion in various tissues, suggesting potential for breakthroughs in liver research as well.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Muesch, Anne — Albert Einstein College of Medicine
- Study coordinator: Muesch, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.