How lithium affects certain enzymes related to bipolar disorder and dementia
Molecular mechanisms of lithium action on kinases
This study looks at how lithium, a common medication for bipolar disorder, works on certain enzymes in the body to help improve treatment, so people with bipolar disorder can better understand how their medicine affects them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10903958 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms by which lithium, a common treatment for bipolar disorder, influences specific enzymes known as kinases. By examining how lithium interacts with these enzymes, the study aims to uncover why some kinases are affected by lithium while others are not. The approach combines advanced simulations and experimental techniques to explore these interactions at a molecular level. Patients with bipolar disorder may find this research relevant as it seeks to enhance the understanding of lithium's therapeutic effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bipolar disorder who are currently receiving or considering lithium treatment.
Not a fit: Patients with bipolar disorder who are not being treated with lithium or those with other unrelated mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bipolar disorder and potentially reduce the risk of dementia in affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding the effects of lithium on various biological processes, indicating that this approach has potential for success.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Varma, Sameer — University of South Florida
- Study coordinator: Varma, Sameer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.