How Listeria monocytogenes adapts to oxidative stress
Official title: Metabolic changes that promote adaptation of Listeria monocytogenes to oxidative stress and preserving intracellular redox homeostasis
Funded at Mississippi State University · NIH-10793915 · Data updated 2026-11-12
This study is looking at how the bacteria that causes listeriosis, a serious foodborne illness, manages to survive in our bodies when faced with harmful substances, and it hopes to find new ways to help treat infections for people who get sick from it.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | December 6, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $418,270 |
| NIH project number | 1R15AI180880-01 |
| Project ID | NIH-10793915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with listeriosis or are at high risk for severe infections caused by Listeria monocytogenes.
✕Less likely to help
Patients with non-infectious conditions or those not affected by Listeria monocytogenes will not benefit from this research.
What this research studies
This research investigates how the bacteria Listeria monocytogenes, which causes a serious foodborne illness, adapts its metabolism to survive oxidative stress during infection. The study focuses on understanding the metabolic pathways that the bacteria use to counteract harmful reactive oxygen species in the host environment. By analyzing specific metabolites and the role of a protein called FruR, the researchers aim to uncover new strategies for treating infections caused by this pathogen. This could lead to improved therapeutic approaches for patients suffering from listeriosis.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for listeriosis, potentially reducing mortality rates associated with this infection.
How similar studies have gone: While the specific metabolic adaptations of Listeria monocytogenes to oxidative stress are being explored in this research, similar studies on bacterial resistance mechanisms have shown promising results in the past.
Where this research is happening
-
Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Abdelhamed, Hossam a — Mississippi State University
- Study coordinator: Abdelhamed, Hossam a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.