How lipid regulation affects heart function and calcium signaling
Lipid regulation of Cardiac Excitation-Contraction coupling
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11095985
This study looks at how a substance called angiotensin II affects heart cells and their calcium channels, which are important for heart function, to help us understand how this could lead to better treatments for heart conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11095985 on ClinicalTrials.gov |
What this research studies
This research investigates how acute stimulation by angiotensin II affects calcium channel behavior in heart cells, specifically focusing on the internalization of calcium channels and its implications for heart function. By examining the biochemical pathways involved, the study aims to understand how these processes can lead to both short-term improvements and long-term detrimental effects on cardiac health. Patients may benefit from insights gained about heart function regulation and potential new therapeutic targets for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be experiencing heart-related issues or conditions influenced by calcium signaling.
Not a fit: Patients with non-cardiac conditions or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart conditions that improve cardiac function and prevent long-term damage.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in cardiac function, suggesting that this approach may yield significant insights.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIXON, ROSE ELLEN — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: DIXON, ROSE ELLEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.