How light affects biological clocks in mammals
Official title: The mechanism of extra-visual circadian photoentrainment in mammals
Funded at University of Washington · NIH-11004163 · Data updated 2026-11-12
This study is looking at how certain skin and eye cells in mammals can sense light and help keep our body clocks in sync, which could help us understand how light affects our health and well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $368,743 |
| NIH project number | 5R01GM152641-02 |
| Project ID | NIH-11004163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with circadian rhythm disorders or those affected by conditions related to light exposure.
✕Less likely to help
Patients who do not have any circadian rhythm disorders or related conditions may not receive direct benefits from this research.
What this research studies
This research investigates how certain cells in mammals, particularly in the skin and retina, can directly respond to light and synchronize their internal biological clocks. By focusing on a specific protein called Opn5, the study aims to understand the molecular mechanisms that allow these cells to detect light and communicate this information to neighboring cells. The approach involves examining how light influences cellular signaling and the synchronization of circadian rhythms, which are essential for maintaining health and well-being. Patients may benefit from insights into how light exposure impacts various biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing circadian rhythm-related disorders and improving overall health.
How similar studies have gone: Previous research has shown promising results in understanding circadian rhythms and light exposure, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Buhr, Ethan D — University of Washington
- Study coordinator: Buhr, Ethan D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.