How lifetime cash payments relate to memory and dementia risk in rural South Africa

Cumulative socioeconomic exposures, cash transfer interventions, and later-life cognitive decline and dementia risk in a low-income region of South Africa

NIH-funded research Trustees of Indiana University · NIH-11160779

This project looks at whether regular government cash payments to families can help protect thinking and memory as people age in a low-income South African region.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionTrustees of Indiana University NIH-funded
Lab location1 site (Bloomington, United States)
Project IDNIH-11160779 on NIH RePORTER

What this research studies

If you live in rural South Africa, this project links long-term health surveys, a past randomized cash transfer trial, and regional census records to see how receiving cash at different ages, amounts, and durations relates to memory and dementia later in life. The team connects data from the HAALSI aging cohort, the HPTN 068 cash transfer trial, and the Agincourt Health and Demographic Surveillance System with government program records. Earlier work from this group found that cash transfers helped protect memory and lower dementia risk, and this renewal will look for the optimal payment sizes, timing, and target recipients to get the most protection. The researchers use statistical and causal-analysis methods, including randomized-trial evidence, to compare people with different histories of cash support across the adult life course.

Who could benefit from this research

Good fit: Adults living in low-income, rural South African communities—especially those who received or are eligible for government cash-transfer programs—are the most relevant to this research.

Not a fit: People who live outside the targeted South African region, are not part of the linked databases, or already have advanced dementia are unlikely to receive direct benefit from this project.

Why it matters

Potential benefit: If successful, the findings could help shape cash-transfer policies that better protect thinking and memory and reduce dementia risk in low-income communities.

How similar studies have performed: Previous linked analyses by the same team found protective effects of randomized cash transfers on memory, dementia probability, and mortality, so this work builds on promising prior results.

Where this research is happening

Bloomington, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementia
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.