How lifestyle-related oxidative stress may raise cancer risk
Biomarkers, mechanisms and modulation of oxidative stress associated risk factors in carcinogenesis
Researchers will look for DNA signs of oxidative stress in colorectal tumors and link those signs to patients' long-term lifestyle and inflammation history.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11182627 on NIH RePORTER |
What this research studies
You would be asked to allow use of your tumor tissue and detailed medical and lifestyle records. Investigators will perform whole-genome sequencing and use computational 'mutational signature' methods to find DNA patterns caused by reactive oxygen species (ROS). They will combine multi-omic lab analyses and computational work to study how oxidative stress can promote tumor development and whether those effects can be modified. The team will compare signature levels against long-term lifestyle factors like obesity, diet, and chronic inflammation to see which exposures match the DNA marks.
Who could benefit from this research
Good fit: People with colorectal cancer who can provide tumor tissue and have detailed, longitudinal lifestyle and medical information would be the best candidates.
Not a fit: People without colorectal tumors, without available tumor tissue or detailed lifestyle records, or those expecting immediate new treatments are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could produce a biomarker of lifetime oxidative stress that helps identify people at higher cancer risk and guide prevention or personalized care.
How similar studies have performed: Previous studies have identified mutational signatures for smoking and UV exposure, but a reliable ROS-related mutational signature is not yet established and this application is relatively novel for oxidative stress.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Li, Yun Rose — Beckman Research Institute/city of Hope
- Study coordinator: Li, Yun Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.