How lifestyle factors affect the behavior of nanoparticles in the body
Official title: Individual lifestyle exposure as a determinant for the formation of biomolecule corona on nanoparticles
Funded at University of North Texas Hlth Sci Ctr · NIH-11038577 · Data updated 2026-11-12
This study is looking at how things like stress from being alone or living in crowded places can change how blood proteins stick to tiny particles that might help deliver medicine better to specific parts of the body, which could lead to more personalized treatments for patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas Hlth Sci Ctr NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $74,000 |
| NIH project number | 1R03EB036760-01 |
| Project ID | NIH-11038577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who experience chronic stress or have lifestyle factors that may influence their blood biomolecule composition.
✕Less likely to help
Patients without significant lifestyle stressors or those not receiving nanoparticle-based therapies may not benefit from this research.
What this research studies
This research investigates how different lifestyle exposures, such as stress from social isolation or overcrowding, influence the way biomolecules from the blood adhere to nanoparticles. These nanoparticles are being studied for their potential to deliver drugs more effectively to specific tissues in the body. By using animal models, the research aims to understand the composition of the protein corona that forms around these nanoparticles and how it can affect their targeting ability. This knowledge could lead to improved drug delivery systems that are tailored to individual patient lifestyles.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of nanoparticle-based drug delivery systems, leading to better treatment outcomes for patients.
How similar studies have gone: While the concept of protein corona on nanoparticles is established, this specific investigation into lifestyle factors is relatively novel and has not been extensively tested.
Where this research is happening
-
University of North Texas Hlth Sci Ctr
Fort Worth, United States Active
Researchers
- Principal investigator: Kim, Jayoung — University of North Texas Hlth Sci Ctr
- Study coordinator: Kim, Jayoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.